HGH

GH (Somatotropin) is secreted by the anterior pituitary in all classes of vertebrates. Somatotropin exhibits a wide range of biological activities, including somatic growth, energy metabolism, sexual maturation, and immune functions. In euryhaline teleosts, GH is involved in seawater adaptability. Pituitary gland-derived growth promoting activity was discovered in 1921, and the first GH was isolated in 1944. The primary structure of human GH was first proposed in 1969. Subsequently, several corrections have been added to this sequence, and its primary structure was determined in 1971. During that same period, the structure of bovine and ovine GH was also determined. In 2002, the structure of GH was determined in the sea lamprey, an extant representative of the Agnatha, a group of the most ancient vertebrates. However, it has not yet been determined in the hagfish.